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Meanings of genomic instability in English
Russian
геномная нестабильность Spanish
inestabilidad genómica Genome instability (also genetic instability or genomic instability) refers to a high frequency of mutations within the genome of a cellular lineage.
Synonyms
Examples for "genome instability"
Examples for "genome instability"
1
Our present knowledge of the molecular basis underlying genome instability is extremely limited.
2
Here, we present evidence that MLL2 mutation results in genome instability.
3
Cells with a faulty protective mechanism undergo defective mitosis, leading to genome instability.
4
Human MLL2 knockout cells are characterized by genome instability as well.
5
Defects in the genes encoding the Paf1 complex can cause increased genome instability.
1
However, our data impressively demonstrate the genetic instability in this chromosomal region.
2
Oxidative DNA damage seems to contribute to genetic instability observed in cancer.
3
Background: Latent genetic instability has been associated with an increased risk for several cancers.
4
However, their inherent genetic instability hinders application for prophylactic purposes.
5
Defects in DNA damage responses may underlie genetic instability and malignant progression in melanoma.
Usage of genomic instability in English
1
Cells from patients with genomic instability syndromes have high predisposition to cancer.
2
Deregulated activation of β-catenin in cancer has been correlated with genomic instability.
3
Moreover, the different patterns of alteration imply distinct underlying mechanisms of genomic instability.
4
NOS-induced ROS release leads to DNA damage and genomic instability in DMD hPSC.
5
Although R-loops are normal transcriptional intermediates, they are also associated with genomic instability.
6
Actively transcribed regions of the genome are vulnerable to genomic instability.
7
Rare cells escaping senescence by restoring SKP2 expression display genomic instability.
8
The mechanisms contributing to transcription-associated genomic instability are both complex and incompletely understood.
9
Chromosomal destabilization is one end point of the more general phenomenon of genomic instability.
10
Whether Polθ interacts with canonical DNA repair pathways to prevent genomic instability remains unknown.
11
Such coincidences may result in collisions that trigger genomic instability.
12
The genomic instability, adaptive response formation, genome damage and oxidative status have been investigated.
13
Therefore, persistently increased oxidative stress has been proposed as a mechanism for UV-induced genomic instability.
14
Mechanisms underlying genomic instability in MM are largely unknown.
15
If not properly repaired, these lesions can lead to mutations, genomic instability, and cell death.
16
Nevertheless, several studies indicate that AML cells show high levels of DNA lesions and genomic instability.
This collocation consists of:
Translations for genomic instability
Russian
Genomic instability through the time
Genomic instability across language varieties
United States of America
Common